EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.4.24.B12 | adamts5 endopeptidase deficiency |
17255106 |
ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan. |
unassigned |
0 |
| 3.4.24.B12 | adamts5 endopeptidase deficiency |
21566131 |
Adamts5 Deletion Blocks Murine Dermal Repair through CD44-mediated Aggrecan Accumulation and Modulation of Transforming Growth Factor {beta}1 (TGF{beta}1) Signaling. |
causal interaction
unassigned |
4
0 |
| 3.4.24.B12 | adamts5 endopeptidase deficiency |
23531444 |
Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valves. |
causal interaction
unassigned |
4
0 |
| 3.4.24.B12 | adamts5 endopeptidase deficiency |
27254774 |
ADAMTS5 deficiency protects against non-alcoholic steatohepatitis in obesity. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
4
1
0 |
| 3.4.24.B12 | adamts5 endopeptidase deficiency |
28546218 |
ADAMTS5 Deficiency in Calcified Aortic Valves Is Associated With Elevated Pro-Osteogenic Activity in Valvular Interstitial Cells. |
causal interaction
unassigned |
4
0 |
| 3.4.24.B12 | adamts5 endopeptidase deficiency |
28570296 |
Adamts5 Deficiency Protects Mice from Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration. |
causal interaction
unassigned |
4
0 |
| 3.4.24.B12 | adamts5 endopeptidase deficiency |
30958594 |
ADAMTS5 deficiency in mice does not affect cardiac function. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
4
1
1
0 |
| 3.4.24.B12 | Adenoviridae Infections |
30016600 |
Sox4 is involved in osteoarthritic cartilage deterioration through induction of ADAMTS4 and ADAMTS5. |
causal interaction
unassigned |
3
0 |
| 3.4.24.B12 | Aneurysm |
27156333 |
The Investigation of a Disintegrin and Metalloproteinase with ThromboSpondin Motifs (ADAMTS) 1, 5 and 16 in Thoracic Aortic Aneurysms and Dissections. |
diagnostic usage
ongoing research
unassigned |
4
3
0 |
| 3.4.24.B12 | Aneurysm |
33934089 |
Internal modulation of proteolysis in vascular extracellular matrix remodeling: role of ADAM metallopeptidase with thrombospondin type 1 motif 5 in the development of intracranial aneurysm rupture. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
2
3
0 |
