EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.4.22.64 | Acquired Immunodeficiency Syndrome |
32401674 |
Caspase-11 contributes to pulmonary host defense against Klebsiella pneumoniae and local activation of coagulation. |
causal interaction
ongoing research
therapeutic application
unassigned |
3
4
3
0 |
| 3.4.22.64 | Acute Kidney Injury |
30250284 |
Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury. |
causal interaction
ongoing research
unassigned |
1
3
0 |
| 3.4.22.64 | Acute Kidney Injury |
31230050 |
Caspase-11 Mediates Pyroptosis of Tubular Epithelial Cells and Septic Acute Kidney Injury. |
causal interaction
ongoing research
unassigned |
2
3
0 |
| 3.4.22.64 | Acute Kidney Injury |
31405732 |
The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury. |
diagnostic usage
unassigned |
3
0 |
| 3.4.22.64 | Acute Lung Injury |
28990935 |
Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury. |
ongoing research
therapeutic application
unassigned |
1
1
0 |
| 3.4.22.64 | Acute Lung Injury |
34349759 |
Mechanical Ventilation Exacerbates Poly (I:C) Induced Acute Lung Injury: Central Role for Caspase-11 and Gut-Lung Axis. |
unassigned |
0 |
| 3.4.22.64 | Adenocarcinoma of Lung |
34084280 |
Caspase-11 and AIM2 inflammasome are involved in smoking-induced COPD and lung adenocarcinoma. |
causal interaction
unassigned |
2
0 |
| 3.4.22.64 | Amyotrophic Lateral Sclerosis |
12843244 |
Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis. |
ongoing research
unassigned |
2
0 |
| 3.4.22.64 | Arthritis |
21120997 |
Matrix metalloproteinase 8 deficiency in mice exacerbates inflammatory arthritis through delayed neutrophil apoptosis and reduced caspase 11 expression. |
causal interaction
therapeutic application
unassigned |
1
1
0 |
| 3.4.22.64 | Arthritis, Gouty |
31803174 |
Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
3
1
3 |
