EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.4.22.57 | Adenocarcinoma |
33187551 |
Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
1
4
4
2 |
| 3.4.22.57 | Alzheimer Disease |
15123740 |
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. |
causal interaction
unassigned |
4
0 |
| 3.4.22.57 | Alzheimer Disease |
17942194 |
Presenilin-1 mutation activates the signaling pathway of caspase-4 in endoplasmic reticulum stress-induced apoptosis. |
causal interaction
ongoing research
unassigned |
3
2
0 |
| 3.4.22.57 | Alzheimer Disease |
19931333 |
Caspase-4 is partially cleaved by calpain via the impairment of Ca2+ homeostasis under the ER stress. |
causal interaction
ongoing research
unassigned |
1
3
0 |
| 3.4.22.57 | Amyotrophic Lateral Sclerosis |
20816908 |
Familiar amyotrophic lateral sclerosis (FALS)-linked SOD1 mutation accelerates neuronal cell death by activating cleavage of caspase-4 under ER stress in an in vitro model of FALS. |
ongoing research
unassigned |
2
0 |
| 3.4.22.57 | Arthritis, Rheumatoid |
16137006 |
[Effect of ubiquitin-proteasome pathway on TRAIL inducing apoptosis] |
unassigned |
0 |
| 3.4.22.57 | Asthma |
24136334 |
Elevated expression of the NLRP3 inflammasome in neutrophilic asthma. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
4
1
1
0 |
| 3.4.22.57 | Asthma |
32103022 |
Caspase-11 promotes allergic airway inflammation. |
causal interaction
ongoing research
unassigned |
1
4
0 |
| 3.4.22.57 | Bacterial Infections |
28147281 |
The Atypical Ubiquitin E2 Conjugase UBE2L3 Is an Indirect Caspase-1 Target and Controls IL-1? Secretion by Inflammasomes. |
unassigned |
0 |
| 3.4.22.57 | Bacterial Infections |
31152010 |
Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis. |
ongoing research
therapeutic application
unassigned |
2
1
0 |
