EC Number |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
---|
3.4.22.49 | Blast Crisis |
26087013 |
Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy. |
causal interaction therapeutic application unassigned |
1 2 0 |
3.4.22.49 | Blast Crisis |
26937281 |
c-MYB is a transcriptional regulator of ESPL1/Separase in BCR-ABL-positive chronic myeloid leukemia. |
causal interaction therapeutic application unassigned |
3 1 0 |
3.4.22.49 | Breast Neoplasms |
18728194 |
Overexpression of Separase induces aneuploidy and mammary tumorigenesis. |
causal interaction ongoing research therapeutic application unassigned |
4 1 1 0 |
3.4.22.49 | Breast Neoplasms |
19008095 |
Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: a Swedish prospective case-control study. |
diagnostic usage ongoing research unassigned |
4 3 0 |
3.4.22.49 | Breast Neoplasms |
24276237 |
MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas. |
causal interaction diagnostic usage unassigned |
4 1 0 |
3.4.22.49 | Breast Neoplasms |
24481326 |
Genetically engineered ER? positive breast cancer mouse models. |
causal interaction diagnostic usage therapeutic application unassigned |
3 1 3 0 |
3.4.22.49 | Breast Neoplasms |
25086634 |
ESPL1 is a candidate oncogene of luminal B breast cancers. |
causal interaction diagnostic usage ongoing research therapeutic application |
4 4 2 4 |
3.4.22.49 | Breast Neoplasms |
28177203 |
Biology and insights into the role of cohesin protease separase in human malignancies. |
causal interaction diagnostic usage ongoing research therapeutic application |
3 3 4 1 |
3.4.22.49 | Breast Neoplasms |
28859055 |
Separase is a marker for prognosis and mitotic activity in breast cancer. |
causal interaction diagnostic usage ongoing research therapeutic application |
4 4 1 1 |
3.4.22.49 | Breast Neoplasms |
29780443 |
Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth. |
ongoing research therapeutic application unassigned |
1 1 0 |