EC Number |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
---|
3.4.21.B25 | Adenocarcinoma |
9166946 |
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours. |
causal interaction diagnostic usage ongoing research unassigned |
3 3 2 0 |
3.4.21.B25 | Adenocarcinoma |
28347547 |
PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression. |
causal interaction diagnostic usage ongoing research therapeutic application |
4 3 4 4 |
3.4.21.B25 | Anemia |
18664504 |
Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7. |
causal interaction therapeutic application unassigned |
3 4 0 |
3.4.21.B25 | Anthrax |
9234799 |
A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen. |
causal interaction ongoing research therapeutic application unassigned |
3 1 2 0 |
3.4.21.B25 | Anthrax |
10215603 |
Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain. |
therapeutic application unassigned |
1 0 |
3.4.21.B25 | Breast Neoplasms |
9185698 |
Pro-protein convertase gene expression in human breast cancer. |
diagnostic usage ongoing research unassigned |
3 4 0 |
3.4.21.B25 | Breast Neoplasms |
17909005 |
Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: role of tissue inhibitors of metalloproteinase-1. |
ongoing research therapeutic application unassigned |
1 1 0 |
3.4.21.B25 | Breast Neoplasms |
25333574 |
PACE4 regulates proliferation, migration and invasion in human breast cancer MDA-MB-231 cells. |
causal interaction ongoing research therapeutic application unassigned |
4 4 4 0 |
3.4.21.B25 | Breast Neoplasms |
28347547 |
PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression. |
causal interaction diagnostic usage ongoing research therapeutic application |
4 3 4 4 |
3.4.21.B25 | Carcinogenesis |
9393739 |
Expression of PACE4 in chemically induced carcinomas is associated with spindle cell tumor conversion and increased invasive ability. |
causal interaction ongoing research therapeutic application unassigned |
4 4 1 0 |