EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.4.21.108 | Acute Kidney Injury |
20219823 |
Omi/HtrA2 protease is associated with tubular cell apoptosis and fibrosis induced by unilateral ureteral obstruction. |
causal interaction
unassigned |
4
0 |
| 3.4.21.108 | Adenocarcinoma |
12887511 |
Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
4
4
2 |
| 3.4.21.108 | aldehyde dehydrogenase (nad+) deficiency |
32048867 |
Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle. |
causal interaction
diagnostic usage
ongoing research
unassigned |
4
3
1
0 |
| 3.4.21.108 | Alzheimer Disease |
16258245 |
HtrA2 interacts with A beta peptide but does not directly alter its production or degradation. |
causal interaction
therapeutic application
unassigned |
3
1
0 |
| 3.4.21.108 | Alzheimer Disease |
20938363 |
Localization of HtrA2/Omi immunoreactivity in brains affected by Alzheimer's disease. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
4
4 |
| 3.4.21.108 | Alzheimer Disease |
21163861 |
Altered enzymatic activity and allele frequency of OMI/HTRA2 in Alzheimer's disease. |
causal interaction
diagnostic usage
unassigned |
4
3
0 |
| 3.4.21.108 | Alzheimer Disease |
22273571 |
Immunohistochemical localization of X-linked inhibitor of apoptosis protein in brainstem-type and cortical Lewy bodies. |
diagnostic usage
ongoing research
unassigned |
3
4
0 |
| 3.4.21.108 | Alzheimer Disease |
25288153 |
Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells. |
causal interaction
diagnostic usage
ongoing research
unassigned |
1
1
3
0 |
| 3.4.21.108 | Alzheimer Disease |
30361890 |
Increased Active OMI/HTRA2 Serine Protease Displays a Positive Correlation with Cholinergic Alterations in the Alzheimer's Disease Brain. |
causal interaction
unassigned |
3
0 |
| 3.4.21.108 | Amyotrophic Lateral Sclerosis |
20202124 |
HtrA2/Omi-immunoreactive intraneuronal inclusions in the anterior horn of patients with sporadic and SOD1 mutant amyotrophic lateral sclerosis. |
unassigned |
0 |
