EC Number |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
---|
3.1.4.53 | 3',5'-cyclic-amp phosphodiesterase deficiency |
16213210 |
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. |
causal interaction therapeutic application unassigned |
4 4 0 |
3.1.4.53 | 3',5'-cyclic-amp phosphodiesterase deficiency |
19359377 |
Reduced adiposity and high fat diet-induced adipose inflammation in mice deficient for phosphodiesterase 4B. |
causal interaction therapeutic application unassigned |
4 4 0 |
3.1.4.53 | 3',5'-cyclic-amp phosphodiesterase deficiency |
25457552 |
Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice. |
ongoing research unassigned |
4 0 |
3.1.4.53 | 3',5'-cyclic-amp phosphodiesterase deficiency |
32264695 |
Cardiac Overexpression of PDE4B Blunts ?-Adrenergic Response and Maladaptive Remodeling in Heart Failure. |
causal interaction therapeutic application unassigned |
4 4 0 |
3.1.4.53 | Acquired Immunodeficiency Syndrome |
31231579 |
Novel GFP-fused protein probes for detecting phosphatidylinositol-4-phosphate in the plasma membrane. |
unassigned |
0 |
3.1.4.53 | Acute Kidney Injury |
32622666 |
Rutaecarpine derivative Cpd-6c alleviates acute kidney injury by targeting PDE4B, a key enzyme mediating inflammation in cisplatin nephropathy. |
therapeutic application unassigned |
1 0 |
3.1.4.53 | Acute Lung Injury |
9490659 |
Suppression of acute lung injury in mice by an inhibitor of phosphodiesterase type 4. |
ongoing research therapeutic application unassigned |
3 4 0 |
3.1.4.53 | Acute Lung Injury |
10806144 |
Additive effects of phosphodiesterase-4 inhibition on effects of rSP-C surfactant. |
ongoing research therapeutic application unassigned |
3 4 0 |
3.1.4.53 | Acute Lung Injury |
11907182 |
The selective phosphodiesterase 4 inhibitor RP 73-401 reduced matrix metalloproteinase 9 activity and transforming growth factor-beta release during acute lung injury in mice: the role of the balance between Tumor necrosis factor-alpha and interleukin-10. |
causal interaction therapeutic application unassigned |
3 1 0 |
3.1.4.53 | Acute Lung Injury |
12882446 |
Therapeutic potential of a new phosphodiesterase inhibitor in acute lung injury. |
causal interaction diagnostic usage ongoing research therapeutic application |
4 3 3 4 |