EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.1.16.1 | Chondrocalcinosis |
29688536 |
Inhibition of nucleotide pyrophosphatase/phosphodiesterase 1: implications for developing a calcium pyrophosphate deposition disease modifying drug. |
therapeutic application
unassigned |
3
0 |
| 3.1.16.1 | Genetic Diseases, Inborn |
9778254 |
Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity. |
causal interaction
therapeutic application
unassigned |
4
2
0 |
| 3.1.16.1 | Genetic Diseases, Inborn |
12515398 |
Human FEN-1 can process the 5'-flap DNA of CTG/CAG triplet repeat derived from human genetic diseases by length and sequence dependent manner. |
ongoing research
unassigned |
2
0 |
| 3.1.16.1 | Herpes Simplex |
10516030 |
Picornavirus internal ribosome entry site elements target RNA cleavage events induced by the herpes simplex virus virion host shutoff protein. |
unassigned |
0 |
| 3.1.16.1 | Huntington Disease |
12917330 |
Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instability. |
ongoing research
unassigned |
2
0 |
| 3.1.16.1 | Infections |
23006624 |
A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability. |
causal interaction
unassigned |
2
0 |
| 3.1.16.1 | Leukemia |
9894157 |
Down-regulation of human FEN-1 gene expression during differentiation of promyelocytic leukemia cells. |
causal interaction
ongoing research
unassigned |
4
4
0 |
| 3.1.16.1 | Leukemia |
10771101 |
Gene expression of flap endonuclease-1 during cell proliferation and differentiation. |
causal interaction
ongoing research
unassigned |
1
2
0 |
| 3.1.16.1 | Melanoma |
26318993 |
Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF. |
unassigned |
0 |
| 3.1.16.1 | Neoplasms |
9778254 |
Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity. |
causal interaction
therapeutic application
unassigned |
4
2
0 |
