EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   2.3.2.5 | Alzheimer Disease |
18836460 |
Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology. |
causal interaction
ongoing research
therapeutic application
unassigned |
3
1
4
0 |
| 2.3.2.5 | Alzheimer Disease |
19863057 |
Inhibitors for Human Glutaminyl Cyclase by Structure Based Design and Bioisosteric Replacement. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 2.3.2.5 | Alzheimer Disease |
20383514 |
Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease. |
ongoing research
unassigned |
1
0 |
| 2.3.2.5 | Alzheimer Disease |
21037969 |
PYROGLUTAMATE FORMATION AT THE N-TERMINI OF ABRI MOLECULES IN FAMILIAL BRITISH DEMENTIA IS NOT RESTRICTED TO THE CENTRAL NERVOUS SYSTEM. |
therapeutic application
unassigned |
1
0 |
| 2.3.2.5 | Alzheimer Disease |
21288892 |
Structures of Human Golgi-resident Glutaminyl Cyclase and Its Complexes with Inhibitors Reveal a Large Loop Movement upon Inhibitor Binding. |
therapeutic application
unassigned |
1
0 |
| 2.3.2.5 | Alzheimer Disease |
22970285 |
Disturbed ca(2+) homeostasis increases glutaminyl cyclase expression; connecting two early pathogenic events in Alzheimer's disease in vitro. |
causal interaction
unassigned |
2
0 |
| 2.3.2.5 | Alzheimer Disease |
23207485 |
Increased glutaminyl cyclase expression in peripheral blood of Alzheimer's disease patients. |
causal interaction
diagnostic usage
ongoing research
unassigned |
3
3
2
0 |
| 2.3.2.5 | Alzheimer Disease |
23886302 |
Structure-activity relationships of benzimidazole-based glutaminyl cyclase inhibitors featuring a heteroaryl scaffold. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 2.3.2.5 | Alzheimer Disease |
24164736 |
Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-? load and cognitive decline in Alzheimer's disease. |
ongoing research
unassigned |
2
0 |
| 2.3.2.5 | Alzheimer Disease |
25114069 |
Inhibition of glutaminyl cyclase ameliorates amyloid pathology in an animal model of Alzheimer's disease via the modulation of ?-secretase activity. |
causal interaction
ongoing research
unassigned |
2
2
0 |
