EC Number   |
Disease |
PubMed ID  |
Title of Publication |
Category |
Confidence Level |
|---|
   2.3.1.286 | Neoplasms |
11672522 |
Negative control of p53 by Sir2alpha promotes cell survival under stress. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 2.3.1.286 | Leukemia |
12006491 |
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. |
ongoing research
therapeutic application
unassigned |
1
1
0 |
| 2.3.1.286 | Neoplasms |
12220851 |
Human Sir2 and the 'silencing' of p53 activity. |
unassigned |
0 |
| 2.3.1.286 | Neoplasms |
12297502 |
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. |
ongoing research
therapeutic application
unassigned |
3
1
0 |
| 2.3.1.286 | Neoplasms |
12939617 |
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. |
causal interaction
unassigned |
2
0 |
| 2.3.1.286 | Neoplasms |
12960381 |
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. |
causal interaction
unassigned |
4
0 |
| 2.3.1.286 | Glioma |
12963026 |
Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. |
causal interaction
ongoing research
therapeutic application
unassigned |
3
2
3
0 |
| 2.3.1.286 | Neoplasms |
12963026 |
Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. |
causal interaction
ongoing research
therapeutic application
unassigned |
3
2
3
0 |
| 2.3.1.286 | Neoplasms |
14980222 |
Mammalian SIRT1 represses forkhead transcription factors. |
unassigned |
0 |
| 2.3.1.286 | Starvation |
15486319 |
Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
