EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   2.1.1.33 | Carcinoma, Hepatocellular |
12296377 |
The ATF/CREB site is the key element for transcription of the human RNA methyltransferase like 1(RNMTL1) gene, a newly discovered 17p13.3 gene. |
causal interaction
diagnostic usage
ongoing research
unassigned |
1
1
2
0 |
| 2.1.1.33 | Carcinoma, Hepatocellular |
31463732 |
METTL1 overexpression is correlated with poor prognosis and promotes hepatocellular carcinoma via PTEN. |
causal interaction
diagnostic usage
unassigned |
4
4
0 |
| 2.1.1.33 | Cholangiocarcinoma |
34352206 |
N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
1
1
1
0 |
| 2.1.1.33 | Colonic Neoplasms |
31866582 |
Overexpressed methyltransferase-like 1 (METTL1) increased chemosensitivity of colon cancer cells to cisplatin by regulating miR-149-3p/S100A4/p53 axis. |
unassigned |
0 |
| 2.1.1.33 | Lung Neoplasms |
34371184 |
METTL1/WDR4-mediated m7G tRNA modifications and m7G codon usage promote mRNA translation and lung cancer progression. |
therapeutic application
unassigned |
1
0 |
| 2.1.1.33 | Neoplasms |
25233213 |
tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells. |
causal interaction
therapeutic application
unassigned |
3
3
0 |
| 2.1.1.33 | Neoplasms |
31463732 |
METTL1 overexpression is correlated with poor prognosis and promotes hepatocellular carcinoma via PTEN. |
causal interaction
diagnostic usage
unassigned |
4
4
0 |
| 2.1.1.33 | Neoplasms |
32135185 |
Methyltransferase-like 1 (METTL1) served as a tumor suppressor in colon cancer by activating 7-methyguanosine (m7G) regulated let-7e miRNA/HMGA2 axis. |
diagnostic usage
ongoing research
unassigned |
3
1
0 |
| 2.1.1.33 | Neoplasms |
33692862 |
Methyltransferase-like 1 regulates lung adenocarcinoma A549 cell proliferation and autophagy via the AKT/mTORC1 signaling pathway. |
diagnostic usage
ongoing research
unassigned |
1
3
0 |
| 2.1.1.33 | Neoplasms |
34285249 |
Multi-omics integration of methyltransferase-like protein family reveals clinical outcomes and functional signatures in human cancer. |
causal interaction
diagnostic usage
ongoing research
unassigned |
4
4
3
0 |
