EC Number |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
---|
2.1.1.233 | Adenocarcinoma |
24928782 |
PME-1 modulates protein phosphatase 2A activity to promote the malignant phenotype of endometrial cancer cells. |
causal interaction diagnostic usage ongoing research therapeutic application |
4 3 2 4 |
2.1.1.233 | Alzheimer Disease |
29281045 |
Protein Phosphatase 2A and Its Methylation Modulating Enzymes LCMT-1 and PME-1 Are Dysregulated in Tauopathies of Progressive Supranuclear Palsy and Alzheimer Disease. |
diagnostic usage ongoing research unassigned |
1 2 0 |
2.1.1.233 | Alzheimer Disease |
32341098 |
Reduced Expression of the PP2A Methylesterase, PME-1, or the PP2A Methyltransferase, LCMT-1, Alters Sensitivity to Beta-Amyloid-Induced Cognitive and Electrophysiological Impairments in Mice. |
causal interaction therapeutic application unassigned |
1 3 0 |
2.1.1.233 | Astrocytoma |
19293187 |
PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma. |
causal interaction ongoing research unassigned |
4 4 0 |
2.1.1.233 | Carcinoma, Hepatocellular |
32431540 |
Expression Pattern and Prognostic Utility of PME-1 in Patients with Hepatocellular Carcinoma. |
causal interaction diagnostic usage ongoing research therapeutic application |
4 4 2 2 |
2.1.1.233 | Endometrial Neoplasms |
24928782 |
PME-1 modulates protein phosphatase 2A activity to promote the malignant phenotype of endometrial cancer cells. |
causal interaction diagnostic usage ongoing research therapeutic application |
4 3 2 4 |
2.1.1.233 | Endometrial Neoplasms |
27048286 |
Inhibition of protein methylesterase 1 decreased cancerous phenotypes in endometrial adenocarcinoma cell lines and xenograft tumor models. |
causal interaction ongoing research therapeutic application unassigned |
4 1 4 0 |
2.1.1.233 | Glioblastoma |
27810903 |
NNMT Silencing Activates Tumor Suppressor PP2A, Inactivates Oncogenic STKs, and Inhibits Tumor Forming Ability. |
diagnostic usage ongoing research therapeutic application unassigned |
1 2 4 0 |
2.1.1.233 | Glioma |
19293187 |
PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma. |
causal interaction ongoing research unassigned |
4 4 0 |
2.1.1.233 | Glioma |
27671680 |
PP2A Inhibitor PME-1 Drives Kinase Inhibitor Resistance in Glioma Cells. |
causal interaction diagnostic usage ongoing research therapeutic application |
2 2 2 4 |