EC Number |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
---|
1.3.98.1 | Arthritis |
28196676 |
Dihydroorotate dehydrogenase (DHODH) inhibitors affect ATP depletion, endogenous ROS and mediate S-phase arrest in breast cancer cells. |
causal interaction ongoing research therapeutic application unassigned |
3 3 4 0 |
1.3.98.1 | Arthritis |
28270195 |
Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis. |
causal interaction therapeutic application unassigned |
3 4 0 |
1.3.98.1 | Arthritis, Rheumatoid |
16480261 |
Dual binding mode of a novel series of DHODH inhibitors. |
causal interaction therapeutic application unassigned |
3 4 0 |
1.3.98.1 | Arthritis, Rheumatoid |
21355448 |
Human dihydroorotate dehydrogenase inhibitors, a novel approach for the treatment of autoimmune and inflammatory diseases. |
therapeutic application unassigned |
4 0 |
1.3.98.1 | Arthritis, Rheumatoid |
21861807 |
Recent Developments in the Medicinal Chemistry and Therapeutic Potential of Dihydroorotate Dehydrogenase (DHODH) Inhibitors. |
causal interaction therapeutic application unassigned |
3 4 0 |
1.3.98.1 | Arthritis, Rheumatoid |
22966891 |
Association of DHODH haplotype variants and response to leflunomide treatment in rheumatoid arthritis. |
causal interaction ongoing research therapeutic application unassigned |
2 4 4 0 |
1.3.98.1 | Arthritis, Rheumatoid |
27721149 |
Dihydroorotate dehydrogenase: A drug target for the development of antimalarials. |
causal interaction therapeutic application unassigned |
4 4 0 |
1.3.98.1 | Arthritis, Rheumatoid |
31997699 |
Preparation of human dihydroorotate dehydrogenase for interaction studies with lipid bilayers. |
causal interaction therapeutic application unassigned |
4 4 0 |
1.3.98.1 | Arthritis, Rheumatoid |
32339392 |
Precision Medicine with Leflunomide: Consideration of DHODH Haplotype and Plasma Teriflunomide Concentration can Substantially Modify Outcomes in Patients with Rheumatoid Arthritis. |
diagnostic usage unassigned |
3 0 |
1.3.98.1 | Autoimmune Diseases |
10673429 |
Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents. |
ongoing research therapeutic application unassigned |
1 4 0 |