EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
    1.3.5.2 | Arthritis |
21845515 |
Immunosuppressive Effects and Mechanisms of Leflunomide in Dengue Virus Infection of Human Dendritic Cells. |
ongoing research
therapeutic application
unassigned |
3
3
0 |
| 1.3.5.2 | Arthritis |
22229697 |
Profiling of dihydroorotate dehydrogenase, p38, and JAK inhibitors in the rat adjuvant-induced arthritis model: a translational study. |
therapeutic application
unassigned |
3
0 |
| 1.3.5.2 | Arthritis |
22621375 |
Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 1.3.5.2 | Arthritis, Experimental |
11235018 |
Anti-arthritic effects of KF20444, a new immunosuppressive compound inhibiting dihydroorotate dehydrogenase, on rat collagen-induced arthritis. |
ongoing research
unassigned |
4
0 |
| 1.3.5.2 | Arthritis, Experimental |
15182735 |
Protective and anti-arthritic effects of deer antler aqua-acupuncture (DAA), inhibiting dihydroorotate dehydrogenase, on phosphate ions-mediated chondrocyte apoptosis and rat collagen-induced arthritis. |
diagnostic usage
ongoing research
therapeutic application
unassigned |
3
2
1
0 |
| 1.3.5.2 | Arthritis, Rheumatoid |
10878295 |
The use of leflunomide in the treatment of rheumatoid arthritis: an experimental and clinical review. |
therapeutic application
unassigned |
4
0 |
| 1.3.5.2 | Arthritis, Rheumatoid |
18031184 |
How does leflunomide modulate the immune response in rheumatoid arthritis? |
causal interaction
therapeutic application
unassigned |
2
3
0 |
| 1.3.5.2 | Arthritis, Rheumatoid |
18672895 |
The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 1.3.5.2 | Arthritis, Rheumatoid |
19207032 |
The effect of exon (19C>A) dihydroorotate dehydrogenase gene polymorphism on rheumatoid arthritis treatment with leflunomide. |
ongoing research
unassigned |
3
0 |
| 1.3.5.2 | Arthritis, Rheumatoid |
19605743 |
Dihydroorotate dehydrogenase polymorphism influences the toxicity of leflunomide treatment in patients with rheumatoid arthritis. |
causal interaction
therapeutic application
unassigned |
2
3
0 |
