EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   1.14.13.225 | Adenocarcinoma of Lung |
32360180 |
MICAL2 is a novel nucleocytoplasmic shuttling protein promoting cancer invasion and growth of lung adenocarcinoma. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
4
4
4
0 |
| 1.14.13.225 | Anthracosilicosis |
17657972 |
[Cellular metabolism in nasal lining and buccal epithelium in coal miners] |
ongoing research
unassigned |
4
0 |
| 1.14.13.225 | Arrhythmias, Cardiac |
32749237 |
MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII. |
causal interaction
unassigned |
1
0 |
| 1.14.13.225 | Breast Neoplasms |
27430308 |
MICAL1 controls cell invasive phenotype via regulating oxidative stress in breast cancer cells. |
causal interaction
diagnostic usage
ongoing research
unassigned |
4
3
4
0 |
| 1.14.13.225 | Breast Neoplasms |
28719045 |
MICAL2 promotes breast cancer cell migration by maintaining epidermal growth factor receptor (EGFR) stability and EGFR/P38 signalling activation. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
4
4
1 |
| 1.14.13.225 | Breast Neoplasms |
29524295 |
MICAL1 facilitates breast cancer cell proliferation via ROS-sensitive ERK/cyclin D pathway. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
3
4
1 |
| 1.14.13.225 | Breast Neoplasms |
30587593 |
Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells. |
causal interaction
ongoing research
therapeutic application
unassigned |
1
3
1
0 |
| 1.14.13.225 | Breast Neoplasms |
31004710 |
MICAL2 is expressed in cancer associated neo-angiogenic capillary endothelia and it is required for endothelial cell viability, motility and VEGF response. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
1
1
0 |
| 1.14.13.225 | Breast Neoplasms |
34314753 |
MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
1
3
3 |
| 1.14.13.225 | Carcinogenesis |
30555547 |
MICAL2 Mediates p53 Ubiquitin Degradation through Oxidating p53 Methionine 40 and 160 and Promotes Colorectal Cancer Malignance. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
4
4
1 |
