EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   1.1.1.149 | 20alpha-hydroxysteroid dehydrogenase deficiency |
15471942 |
Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase. |
causal interaction
unassigned |
4
0 |
| 1.1.1.149 | Adenocarcinoma |
16417966 |
Aldo-keto reductase (AKR) 1C3: role in prostate disease and the development of specific inhibitors. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
1
4 |
| 1.1.1.149 | Adenocarcinoma |
20661409 |
Suppressed expression of type 2 3alpha/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) in endometrial hyperplasia and carcinoma. |
diagnostic usage
ongoing research
unassigned |
3
1
0 |
| 1.1.1.149 | Adenocarcinoma |
21134280 |
Elevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: implications for prostate cancer progression. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
4
3
3 |
| 1.1.1.149 | Adenocarcinoma |
22670171 |
Aldo-keto reductase family 1 member C3 (AKR1C3) is expressed in adenocarcinoma and squamous cell carcinoma but not small cell carcinoma. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
3
3
1
0 |
| 1.1.1.149 | Adenocarcinoma |
24228104 |
Expression of aldo-keto reductase family 1 member C3 (AKR1C3) in neuroendocrine tumors & adenocarcinomas of pancreas, gastrointestinal tract, and lung. |
causal interaction
diagnostic usage
ongoing research
unassigned |
2
2
4
0 |
| 1.1.1.149 | Adenocarcinoma |
29891491 |
AKR1C3 Inhibitor KV-37 Exhibits Antineoplastic Effects and Potentiates Enzalutamide in Combination Therapy in Prostate Adenocarcinoma Cells. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
2
4
4 |
| 1.1.1.149 | Adenoma |
19026713 |
Estrogen biosynthesis in human H295 adrenocortical carcinoma cells. |
diagnostic usage
ongoing research
therapeutic application
unassigned |
3
1
2
0 |
| 1.1.1.149 | Arthritis |
34541028 |
Dysregulated androgen synthesis and anti-androgen resistance in advanced prostate cancer. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 1.1.1.149 | Astrocytoma |
22964423 |
Inducible protection of human astrocytoma 1321N1 cells against hydrogen peroxide and aldehyde toxicity by 7-hydroxycoumarin is associated with the upregulation of aldo-keto reductases. |
ongoing research
unassigned |
4
0 |
