EC Number   |
Disease |
PubMed ID |
Title of Publication  |
Category |
Confidence Level |
|---|
   3.4.22.53 | Neoplasms |
31217905 |
1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours. |
causal interaction
diagnostic usage
ongoing research
unassigned |
3
2
1
0 |
| 3.4.22.53 | Wolfram Syndrome |
25422446 |
A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
3
4
0 |
| 3.4.22.53 | Starvation |
18055788 |
A key role for calpains in retinal ganglion cell death. |
causal interaction
therapeutic application
unassigned |
1
1
0 |
| 3.4.22.53 | Hypertension |
26248159 |
Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
4
3
2
0 |
| 3.4.22.53 | Pulmonary Arterial Hypertension |
26248159 |
Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
4
3
2
0 |
| 3.4.22.53 | Alzheimer Disease |
9296555 |
Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease. |
causal interaction
ongoing research
unassigned |
3
1
0 |
| 3.4.22.53 | Cataract |
2998702 |
Age-related changes of calpain II and alpha-crystallin in the lens of hereditary cataract (Nakano) mouse. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
1
1
0 |
| 3.4.22.53 | Cataract |
8395520 |
alpha-Crystallin chaperone activity is reduced by calpain II in vitro and in selenite cataract. |
ongoing research
unassigned |
3
0 |
| 3.4.22.53 | Muscular Dystrophy, Duchenne |
16815350 |
Altered expression, intracellular distribution and activity of lymphocyte calpain II in Duchenne muscular dystrophy. |
diagnostic usage
ongoing research
unassigned |
3
3
0 |
| 3.4.22.53 | Cataract |
1848210 |
Amelioration of cataracts and proteolysis in cultured lenses by cysteine protease inhibitor E64. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
2
4
0 |
