EC Number |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
---|
3.4.22.53 | Alzheimer Disease |
1718565 |
Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease. |
causal interaction diagnostic usage ongoing research therapeutic application |
2 1 3 1 |
3.4.22.53 | Alzheimer Disease |
9296555 |
Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease. |
causal interaction ongoing research unassigned |
3 1 0 |
3.4.22.53 | Alzheimer Disease |
9654354 |
m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains. |
causal interaction ongoing research therapeutic application unassigned |
1 3 1 0 |
3.4.22.53 | Alzheimer Disease |
11516996 |
The calpain family and human disease. |
causal interaction diagnostic usage unassigned |
4 1 0 |
3.4.22.53 | Alzheimer Disease |
12070670 |
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2. |
causal interaction diagnostic usage ongoing research therapeutic application |
3 2 2 2 |
3.4.22.53 | Alzheimer Disease |
30177812 |
Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects. |
causal interaction ongoing research unassigned |
3 2 0 |
3.4.22.53 | Brain Injuries |
9469158 |
Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study. |
causal interaction diagnostic usage ongoing research therapeutic application |
3 3 4 1 |
3.4.22.53 | Breast Neoplasms |
18332219 |
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion. |
causal interaction ongoing research therapeutic application unassigned |
4 3 1 0 |
3.4.22.53 | Breast Neoplasms |
21140455 |
Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy. |
causal interaction diagnostic usage ongoing research therapeutic application |
4 3 4 4 |
3.4.22.53 | Breast Neoplasms |
29848352 |
Cytoplasmic FOXP1 expression is correlated with ER and calpain II expression and predicts a poor outcome in breast cancer. |
causal interaction diagnostic usage ongoing research unassigned |
4 3 3 0 |