EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category  |
Confidence Level |
|---|
   3.4.22.53 | Alzheimer Disease |
30177812 |
Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects. |
causal interaction
ongoing research
unassigned |
3
2
0 |
| 3.4.22.53 | Arthritis |
7632090 |
Appearance of calpain correlates with arthritis and cartilage destruction in collagen induced arthritic knee joints of mice. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
2
2
3
1 |
| 3.4.22.53 | Breast Neoplasms |
18332219 |
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
3
1
0 |
| 3.4.22.53 | Breast Neoplasms |
27323818 |
The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
4
2
1 |
| 3.4.22.53 | Carcinoma, Non-Small-Cell Lung |
15471877 |
Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion. |
causal interaction
ongoing research
unassigned |
4
1
0 |
| 3.4.22.53 | Cataract |
2536646 |
Calpain II in human lens. |
causal interaction
unassigned |
4
0 |
| 3.4.22.53 | Cataract |
3011481 |
Purification of calpain II from rat lens and determination of endogenous substrates. |
causal interaction
unassigned |
4
0 |
| 3.4.22.53 | Cataract |
7821381 |
Calpains in lens epithelium from patients with cataract. |
causal interaction
unassigned |
1
0 |
| 3.4.22.53 | Cataract |
8125740 |
Cataract and the acceleration of calpain-induced beta-crystallin insolubilization occurring during normal maturation of rat lens. |
causal interaction
ongoing research
unassigned |
3
2
0 |
| 3.4.22.53 | Cataract |
9733588 |
Protein for Lp82 calpain is expressed and enzymatically active in young rat lens. |
causal interaction
unassigned |
1
0 |
