EC Number   |
Disease |
PubMed ID  |
Title of Publication |
Category |
Confidence Level |
|---|
   3.4.24.82 | Arthritis |
12020478 |
Aggrecanase-mediated cartilage degradation. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 3.4.24.82 | Joint Diseases |
12202483 |
Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites. |
causal interaction
therapeutic application
unassigned |
1
1
0 |
| 3.4.24.82 | Osteoarthritis |
12202483 |
Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites. |
causal interaction
therapeutic application
unassigned |
1
1
0 |
| 3.4.24.82 | Hydronephrosis |
12386284 |
A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 null mutant mice develop renal lesions mimicking obstructive nephropathy. |
causal interaction
therapeutic application
unassigned |
1
1
0 |
| 3.4.24.82 | Neoplasms |
12527424 |
Differential expression of plasminogen activator inhibitor-1, tumor necrosis factor-alpha, TNF-alpha converting enzyme and ADAMTS family members in murine fat territories. |
diagnostic usage
ongoing research
unassigned |
1
3
0 |
| 3.4.24.82 | Arthritis |
12755694 |
Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters. |
causal interaction
unassigned |
1
0 |
| 3.4.24.82 | Brain Neoplasms |
14505115 |
Proteases in brain tumour progression. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
4
3
1
0 |
| 3.4.24.82 | Arthritis, Rheumatoid |
14534304 |
Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid. |
causal interaction
unassigned |
4
0 |
| 3.4.24.82 | Chondrosarcoma |
14701864 |
ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1. |
ongoing research
unassigned |
1
0 |
| 3.4.24.82 | Neoplasms |
14996435 |
High-density lipoprotein subfraction 3 decreases ADAMTS-1 expression induced by lipopolysaccharide and tumor necrosis factor-alpha in human endothelial cells. |
ongoing research
unassigned |
3
0 |
