EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level  |
|---|
   3.4.24.82 | Aortic Aneurysm, Thoracic |
23245439 |
ADAMTS-1 and ADAMTS-4 levels are elevated in thoracic aortic aneurysms and dissections. |
causal interaction
diagnostic usage
unassigned |
3
4
0 |
| 3.4.24.82 | Aortic Rupture |
28955046 |
Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice. |
causal interaction
ongoing research
unassigned |
2
4
0 |
| 3.4.24.82 | Arteriovenous Fistula |
20598569 |
Increased expression of HIF-1alpha, VEGF-A and its receptors, MMP-2, TIMP-1, and ADAMTS-1 at the venous stenosis of arteriovenous fistula in a mouse model with renal insufficiency. |
ongoing research
therapeutic application
unassigned |
2
1
0 |
| 3.4.24.82 | Arteriovenous Fistula |
24732590 |
Adventitial delivery of lentivirus-shRNA-ADAMTS-1 reduces venous stenosis formation in arteriovenous fistula. |
ongoing research
therapeutic application
unassigned |
1
1
0 |
| 3.4.24.82 | Arthritis |
10827174 |
The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage. |
unassigned |
0 |
| 3.4.24.82 | Arthritis, Rheumatoid |
14534304 |
Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid. |
causal interaction
unassigned |
4
0 |
| 3.4.24.82 | Arthritis, Rheumatoid |
15161923 |
ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan. |
unassigned |
0 |
| 3.4.24.82 | Arthritis, Rheumatoid |
16099106 |
Aggrecanase-1 (ADAMTS-4) interacts with alpha1-antitrypsin. |
causal interaction
therapeutic application
unassigned |
3
1
0 |
| 3.4.24.82 | Arthritis, Rheumatoid |
22324945 |
Interleukin-6 upregulates expression of ADAMTS-4 in fibroblast-like synoviocytes from patients with rheumatoid arthritis. |
causal interaction
ongoing research
unassigned |
2
4
0 |
| 3.4.24.82 | Arthritis, Rheumatoid |
23137648 |
The low binding affinity of ADAMTS4 for citrullinated fibronectin may contribute to the destruction of joint cartilage in rheumatoid arthritis. |
causal interaction
unassigned |
2
0 |
