EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category  |
Confidence Level |
|---|
   3.4.22.53 | Hypersensitivity |
12460542 |
Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12. |
causal interaction
unassigned |
4
0 |
| 3.4.22.53 | Hypertension, Renovascular |
25990280 |
Transcriptional regulation of calcium-activated neutral protease in cardiomyocytes of hypertensive rats. |
causal interaction
unassigned |
1
0 |
| 3.4.22.53 | Lung Neoplasms |
19568240 |
Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
3
1
0 |
| 3.4.22.53 | Lung Neoplasms |
32069035 |
Noninvasive Early Detection of Calpain 2-Enriched Non-Small Cell Lung Cancer Using a Human Serum Albumin-Bounded Calpain 2 Nanosensor. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
4
3
1
0 |
| 3.4.22.53 | Neoplasms |
16574073 |
mu-Calpain is involved in the regulation of TNF-alpha-induced matrix metalloproteinase-3 release in a rheumatoid synovial cell line. |
causal interaction
unassigned |
3
0 |
| 3.4.22.53 | Neoplasms |
18234454 |
NRF-1, and AP-1 regulate the promoter of the human calpain small subunit 1 (CAPNS1) gene. |
causal interaction
unassigned |
4
0 |
| 3.4.22.53 | Neoplasms |
21305563 |
CALPAIN activity is increased in skeletal muscle from gastric cancer patients with no or minimal weight loss. |
causal interaction
diagnostic usage
ongoing research
unassigned |
4
3
2
0 |
| 3.4.22.53 | Neoplasms |
22183788 |
Calpain 2 is required for the invasion of glioblastoma cells in the zebrafish brain microenvironment. |
causal interaction
ongoing research
unassigned |
4
3
0 |
| 3.4.22.53 | Neoplasms |
22427650 |
Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
4
4 |
| 3.4.22.53 | Neoplasms |
22435971 |
Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
4
4
4 |
