EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.4.22.53 | Alzheimer Disease |
30177812 |
Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects. |
causal interaction
ongoing research
unassigned |
3
2
0 |
| 3.4.22.53 | Amyotrophic Lateral Sclerosis |
32937436 |
Calpain-2 as a therapeutic target in repeated concussion-induced neuropathy and behavioral impairment. |
unassigned |
0 |
| 3.4.22.53 | Anthrax |
24085852 |
Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis. |
therapeutic application
unassigned |
1
0 |
| 3.4.22.53 | Aortic Aneurysm |
19720936 |
Proteomic analysis in aortic media of patients with Marfan syndrome reveals increased activity of calpain 2 in aortic aneurysms. |
causal interaction
unassigned |
1
0 |
| 3.4.22.53 | Aortic Aneurysm, Abdominal |
23977256 |
Calpain-2 Compensation Promotes Angiotensin II-Induced Ascending and Abdominal Aortic Aneurysms in Calpain-1 Deficient Mice. |
causal interaction
ongoing research
therapeutic application
unassigned |
2
2
2
0 |
| 3.4.22.53 | Aortic Aneurysm, Abdominal |
33761765 |
Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice. |
causal interaction
ongoing research
therapeutic application
unassigned |
2
3
1
0 |
| 3.4.22.53 | Arsenic Poisoning |
24641850 |
[Effects of arsenic poisoning on neuronal cell apoptosis and mRNA and protein expression of calpain 1, calpain 2, and cdk5/p25]. |
diagnostic usage
ongoing research
unassigned |
1
3
0 |
| 3.4.22.53 | Arthritis |
7632090 |
Appearance of calpain correlates with arthritis and cartilage destruction in collagen induced arthritic knee joints of mice. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
2
2
3
1 |
| 3.4.22.53 | Arthritis |
15501405 |
Implication of prostaglandin E(2) in TNF-alpha-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs. |
ongoing research
unassigned |
4
0 |
| 3.4.22.53 | Arthritis, Rheumatoid |
10600505 |
Inflammatory cytokines induced down-regulation of m-calpain mRNA expression in fibroblastic synoviocytes from patients with osteoarthritis and rheumatoid arthritis. |
causal interaction
diagnostic usage
ongoing research
unassigned |
3
3
2
0 |
