EC Number   |
Disease  |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.4.22.49 | Breast Neoplasms |
30097312 |
EarlyR: A Robust Gene Expression Signature for Predicting Outcomes of Estrogen Receptor-Positive Breast Cancer. |
unassigned |
0 |
| 3.4.22.49 | Breast Neoplasms |
32337480 |
Independent Validation of EarlyR Gene Signature in BIG 1-98: A Randomized, Double-Blind, Phase III Trial Comparing Letrozole and Tamoxifen as Adjuvant Endocrine Therapy for Postmenopausal Women With Hormone Receptor-Positive, Early Breast Cancer. |
ongoing research
therapeutic application
unassigned |
1
1
0 |
| 3.4.22.49 | Breast Neoplasms |
32546141 |
A prognostic model based on cell-cycle control predicts outcome of breast cancer patients. |
unassigned |
0 |
| 3.4.22.49 | Carcinogenesis |
17210788 |
A mutation in separase causes genome instability and increased susceptibility to epithelial cancer. |
causal interaction
unassigned |
3
0 |
| 3.4.22.49 | Carcinogenesis |
18728194 |
Overexpression of Separase induces aneuploidy and mammary tumorigenesis. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
1
1
0 |
| 3.4.22.49 | Carcinogenesis |
19351757 |
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
4
1 |
| 3.4.22.49 | Carcinogenesis |
19497291 |
Development and validation of a fluorogenic assay to measure separase enzyme activity. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
4
2 |
| 3.4.22.49 | Carcinogenesis |
21799785 |
Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice. |
causal interaction
ongoing research
therapeutic application
unassigned |
1
1
1
0 |
| 3.4.22.49 | Carcinogenesis |
24525869 |
Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
4
3
4
0 |
| 3.4.22.49 | Carcinogenesis |
24792645 |
Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
4
1 |
