EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category  |
Confidence Level |
|---|
   3.4.24.82 | Intervertebral Disc Degeneration |
31751427 |
APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix. |
causal interaction
unassigned |
2
0 |
| 3.4.24.82 | Myocarditis |
20006601 |
ADAMTS-1 contributes to the antifibrotic effect of captopril by accelerating the degradation of type I collagen in chronic viral myocarditis. |
causal interaction
ongoing research
unassigned |
2
4
0 |
| 3.4.24.82 | Neoplasms |
20664926 |
Expression of ADAMTS4 in Ewing's sarcoma. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
4
4 |
| 3.4.24.82 | Neoplasms |
25786261 |
ADAMTS expression in colorectal cancer. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
4
1 |
| 3.4.24.82 | Neoplasms |
27707582 |
Time-Dependent Effects of Arthroscopic Conditions on Human Articular Cartilage: An In Vivo Study. |
causal interaction
unassigned |
3
0 |
| 3.4.24.82 | Neoplasms |
31415758 |
Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1. |
causal interaction
diagnostic usage
ongoing research
unassigned |
3
1
2
0 |
| 3.4.24.82 | Neoplasms |
32130380 |
ADAMTS4 is upregulated in colorectal cancer and could be a useful prognostic indicator of colorectal cancer. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
4
4
2 |
| 3.4.24.82 | Osteoarthritis |
17311924 |
Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate. |
causal interaction
unassigned |
2
0 |
| 3.4.24.82 | Osteoarthritis |
19329309 |
Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors. |
causal interaction
unassigned |
3
0 |
| 3.4.24.82 | Osteoarthritis |
21417219 |
Discovery of (1S,2R,3R)-2,3-Dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: Novel and Highly Selective Aggrecanase Inhibitors. |
causal interaction
unassigned |
1
0 |
