EC Number   |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
|---|
   3.4.24.71 | 0.0000012 |
- |
RO 67-7447 |
- |
701191 |
| 3.4.24.71 | 0.0000058 |
- |
CGS 34043 |
human recombinant ECE-1 overexpressed in CHO cells |
701191 |
| 3.4.24.71 | 0.000011 |
- |
CGS 34226 |
human recombinant ECE-1 overexpressed in CHO cells |
701191 |
| 3.4.24.71 | 0.000017 |
- |
CGS 26303 |
optimized form of inhibitor, human recombinant ECE-1 overexpressed in CHO cells |
701191 |
| 3.4.24.71 | 0.0000198 |
- |
(3R,5S)-1-(5-propylpyrimidin-2-yl)-5-(2,4,5-trifluorobenzyloxymethyl)pyrrolidine-3-thiol trifluoroacetate |
IC50: 0.0000198 mM |
669782 |
| 3.4.24.71 | 0.0000215 |
- |
(2S,4R)-4-acetylsulfanyl-2-(2,4,5-trifluorobenzyloxymethyl)pyrrolidine-1-carboxylic acid 2-methoxycarbonylphenylester |
IC50: 0.0000215 mM |
669782 |
| 3.4.24.71 | 0.000022 |
- |
CGS 35066 |
COS-1 cell membrane with overexpression of human ECE-1 |
701191 |
| 3.4.24.71 | 0.000039 |
- |
N5-(2,2-dimethylpropyl)-1-(2-fluorobenzyl)-N2-[3-[(4-sulfamoylphenyl)carbamoyl]phenyl]-1H-indole-2,5-dicarboxamide |
IC50: 0.000039 mM |
667961 |
| 3.4.24.71 | 0.000042 |
- |
SM-19712 |
in vitro result, in vivo potency is lower than expected compared to in vitro result |
701191 |
| 3.4.24.71 | 0.000055 |
- |
CGS 35601 |
- |
701191 |
