EC Number |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
---|
3.4.21.112 | 0.000008 |
- |
N-[2-(2-chlorophenyl)ethyl]-4-[[3-(2-methylphenyl)piperidin-1-yl]methyl]-N-pyrrolidin-3-ylbenzamide |
most potent inhibitor |
685579 |
3.4.21.112 | 0.000029 |
- |
4-(6-azabicyclo[3.2.1]oct-6-ylmethyl)-N-[2-(2-methoxyphenyl)ethyl]-N-pyrrolidin-3-ylbenzamide |
- |
685579 |
3.4.21.112 | 0.000037 |
- |
N-[2-(2-methoxyphenyl)ethyl]-4-[[3-(2-methylphenyl)piperidin-1-yl]methyl]-N-pyrrolidin-3-ylbenzamide |
- |
685579 |
3.4.21.112 | 0.000095 |
- |
4-(2-azabicyclo[2.2.1]hept-2-ylmethyl)-N-[2-(2-methoxyphenyl)ethyl]-N-pyrrolidin-3-ylbenzamide |
- |
685579 |
3.4.21.112 | 0.0001 |
- |
4-([[(1S 2S)-2-hydroxycyclohexyl]amino]methyl)-N-[2-(2-methoxyphenyl)ethyl]-N-pyrrolidin-3-ylbenzamide |
- |
685579 |
3.4.21.112 | 0.00014 |
- |
4-[[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-pyrrolidin-3-ylbenzamide |
- |
685579 |
3.4.21.112 | 0.00016 |
- |
1-(4-[[2-(2-methoxyphenyl)ethyl](pyrrolidin-3-yl)carbamoyl]benzyl)piperidine-3-carboxamide |
- |
685579 |
3.4.21.112 | 0.00017 |
- |
4-[(diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-pyrrolidin-3-yl]benzamide |
- |
685579 |
3.4.21.112 | 0.000175 |
- |
(R)-4-((diethylamino)methyl)-N-(2-methoxyphenethyl)-N-(pyrrolidin-3-yl)benzamide |
inhibitory profile is determined by measuring the luciferase activity of a transfected sterol regulatory element (SRE)-TATA-luciferase construct into HEK-293 cells |
699750 |
3.4.21.112 | 0.00025 |
- |
N-[2-(2-methoxyphenyl)ethyl]-4-(piperidin-1-ylmethyl)-N-pyrrolidin-3-ylbenzamide |
- |
685579 |