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EC Number IC50 Value IC50 Value Maximum Inhibitor Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.7.12.20.0000012 - 4-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]-3-hydroxy-4-oxobutanamide cascade IC50 681316
Display the word mapDisplay the reaction diagram Show all sequences 2.7.12.20.000004 - 4-(2-fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide colon26 cellular assay 681316
Display the word mapDisplay the reaction diagram Show all sequences 2.7.12.20.000005 - 4-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide colon26 cellular assay 681316
Display the word mapDisplay the reaction diagram Show all sequences 2.7.12.20.0000052 - CH4987655 inhibition of MEK1, pH and temperature not specified in the publication 740419
Display the word mapDisplay the reaction diagram Show all sequences 2.7.12.20.0000068 0.000124 4-(4-bromo-2-fluorophenylamino)-1-methylpyridin-2(1H)-one selective anthranilic acid type inhibitors, residues K97, I141, M143, F129, V127, I126, L118, F209, V211, and S212 of MEK1/2 are important for interaction with the inhibitor, noncompetitive to ATP, inhibition of ERK phosphorylation by MEK1/2 by the deriva 665990
Display the word mapDisplay the reaction diagram Show all sequences 2.7.12.20.000014 - selumetinib inhibition of MEK1 phosphorylation of ERK2, pH and temperature not specified in the publication 740419
Display the word mapDisplay the reaction diagram Show all sequences 2.7.12.20.000016 - CI-1040 clinical candidate, inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay 681316
Display the word mapDisplay the reaction diagram Show all sequences 2.7.12.20.0000174 - 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide cascade IC50 681316
Display the word mapDisplay the reaction diagram Show all sequences 2.7.12.20.000018 - 4-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide cascade IC50 681316
Display the word mapDisplay the reaction diagram Show all sequences 2.7.12.20.000018 - 4-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide inhibition of the Raf-MEK-ERK cascade in an isolated enzyme assay 681316
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