EC Number   |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
|---|
   2.7.1.127 | -999 |
- |
chlorogenic acid |
IC > 0.1 |
687650 |
| 2.7.1.127 | -999 |
- |
chlorogenic acid |
IP3K-A, IC > 0.1 |
687650 |
| 2.7.1.127 | -999 |
- |
chlorogenic acid |
IP3K-C, IC > 0.1 |
687650 |
| 2.7.1.127 | -999 |
- |
F-actin |
the full length form of inositol 1,4,5-trisphosphate-3-kinase-A bundles F-actin in a concentration dependent manner, inhibition of the initial rate of gelsolin induces F-actin severing and the degree of bundling are half maximal at an similar concentration of about 300 nM, whereas inhibition of the rate of actin depolymerization after dilution to 100 nM actin is half maximal at about 30 nM, the much lower EC 50 for the latter effect may reflect the high affinity of enzyme for binding to F actin |
699006 |
| 2.7.1.127 | -999 |
- |
more |
RnIP3K-C including the calmodulin binding and the catalytic domain shows a 3-fold lower IC50 value for 3',4',7,8-tetrahydroxyflavone than RnIP3K including only the calmodulin binding domain. The maximum degree of inhibition is unchanged. Together with the finding that Ca2+-calmodulin partly reverses IP3K inhibition indicates a facilitating but not essential involvement of the calmodulin binding domain in inhibitor binding. |
687650 |
| 2.7.1.127 | 0.000036 |
- |
ellagic acid |
IP3K-A, maximal inhibition 75% |
687650 |
| 2.7.1.127 | 0.000058 |
- |
gossypol |
IP3K-A, maximal inhibition 100% |
687650 |
| 2.7.1.127 | 0.000062 |
- |
aurintricarboxylic acid |
IP3K-C, maximal inhibition 100% |
687650 |
| 2.7.1.127 | 0.000094 |
- |
epicatechin-3-gallate |
IP3K-A, maximal inhibition 100% |
687650 |
| 2.7.1.127 | 0.00011 |
- |
aurintricarboxylic acid |
- |
687650 |
