EC Number   |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
|---|
   2.3.1.22 | -999 |
- |
more |
MGAT2 inhibitors, pIC50 values, overview |
735755 |
| 2.3.1.22 | -999 |
- |
shRNA-adenovirus |
infection with 60000000000 particles per animal (dose limit of no effect of control particles) leads to 83% decreased mRNA levels on day 5, 92% decrease on day 16 post-injection, associated with reduces hepatic MGAT and LPGAT activities (pH 6.4, 25°C), slight body weight reduction despite normal food consumption throughout most of the experimental treatment period (only 15% reduction on day 2), reduced serum triacylglycerols and cholesterol but increased total cholesterol accumulation in the liver |
705006 |
| 2.3.1.22 | 0.0000002 |
- |
(6S)-4-(5-cyclopropylthiophen-2-yl)-3-(2,5-dihydro-1H-tetrazol-5-yl)-6-[2-fluoro-4-(4,4,4-trifluorobutoxy)phenyl]-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one |
pH not specified in the publication, temperature not specified in the publication |
757403 |
| 2.3.1.22 | 0.0000003 |
- |
3-(2,5-dihydro-1H-tetrazol-5-yl)-4-(5-ethylthiophen-2-yl)-6-[4-[(6,6,6-trifluorohexyl)oxy]-2-(trifluoromethyl)phenyl]pyridin-2(1H)-one |
pH not specified in the publication, temperature not specified in the publication |
757403 |
| 2.3.1.22 | 0.00000038 |
- |
2-(cyclobutylsulfanyl)-6-(3-[[(2,3-dihydro-1H-inden-2-yl)methyl]amino]propanoyl)-3-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one |
pH not specified in the publication, temperature not specified in the publication |
757403 |
| 2.3.1.22 | 0.0000006 |
- |
N-(2,4-difluorophenyl)-7-(2-oxopyrrolidin-1-yl)-1-phenyl-2,3-dihydro-1H-indole-5-sulfonamide |
pH 7.4, 23°C |
756664 |
| 2.3.1.22 | 0.00000064 |
- |
2-(cyclobutylsulfanyl)-3-phenyl-6-[([5-[4-(trifluoromethyl)phenoxy]pentyl]amino)acetyl]-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one |
pH not specified in the publication, temperature not specified in the publication |
757403 |
| 2.3.1.22 | 0.00000073 |
- |
N-[[(6'S)-5-(2-hydroxypropan-2-yl)-2'-oxo-6'-[4-(4,4,4-trifluorobutoxy)phenyl]-6'-(trifluoromethyl)-1',2',5',6'-tetrahydro[2,4'-bipyridin]-3'-yl]methyl]-2-(methanesulfonyl)acetamide |
pH not specified in the publication, temperature not specified in the publication |
757403 |
| 2.3.1.22 | 0.00000085 |
- |
(1r,4r)-4-([[(3,3,4,4,4-pentafluoro-2-methylbutan-2-yl)oxy]carbonyl]amino)cyclohexyl 5-[(4-chloro-2,6-difluorophenyl)sulfamoyl]-7-(2-oxopyrrolidin-1-yl)-2,3-dihydro-1H-indole-1-carboxylate |
pH not specified in the publication, temperature not specified in the publication |
756729 |
| 2.3.1.22 | 0.000001 |
- |
(1S)-4'-(2-cyclopropyl-3H-pyrrol-4-yl)-5'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-5-(4,4,4-trifluorobutoxy)-2,3-dihydro-1'H-spiro[indene-1,2'-pyridin]-6'(3'H)-one |
pH not specified in the publication, temperature not specified in the publication |
757403 |
