EC Number |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
---|
1.5.1.5 | 0.000036 |
- |
methotrexate |
wild type enzyme |
700281 |
1.5.1.5 | 0.000041 |
- |
methotrexate |
dhch1-/pXNG4-DHCH1 mutant, FV1 line |
700281 |
1.5.1.5 | 0.0004 |
- |
2,4-diamino-6-benzyl-5-(3-phenylpropyl)-pyrimidine |
dhch1-/pXNG4-DHCH1 mutant, FV1 line |
700281 |
1.5.1.5 | 0.00044 |
- |
2,4-diamino-6-benzyl-5-(3-phenylpropyl)-pyrimidine |
wild type enzyme |
700281 |
1.5.1.5 | 0.00068 |
- |
2,4-diamino-6-(3,4-dichlorophenoxy)-quinazoline |
wild type enzyme |
700281 |
1.5.1.5 | 0.00076 |
- |
2,4-diamino-6-(3,4-dichlorophenoxy)-quinazoline |
dhch1-/pXNG4-DHCH1 mutant, FV1 line |
700281 |
1.5.1.5 | 0.0011 |
- |
(2S)-2-[[4-[(6aR)-3-amino-1,9-dioxo-5,6,6a,7-tetrahydro-4H-imidazol[3,4-f]pteridin-8-yl]benzoyl]amino]pentanedioic acid |
wild type enzyme |
700281 |
1.5.1.5 | 0.0011 |
- |
(2S)-2-[[4-[(6aR)-3-amino-1,9-dioxo-5,6,6a,7-tetrahydro-4H-imidazo[3,4-f]pteridin-8-yl]benzoyl]amino]pentanedioic acid |
50% growth inhibition of wild-type cell line |
700281 |
1.5.1.5 | 0.0033 |
- |
(2S)-2-[[4-[(6aR)-3-amino-1,9-dioxo-5,6,6a,7-tetrahydro-4H-imidazo[3,4-f]pteridin-8-yl]benzoyl]amino]pentanedioic acid |
50% growth inhibition of null mutant with plasmid expressing formate-tetrahydrofolate ligase |
700281 |
1.5.1.5 | 0.0037 |
- |
(2S)-2-[[4-[(6aR)-3-amino-1,9-dioxo-5,6,6a,7-tetrahydro-4H-imidazo[3,4-f]pteridin-8-yl]benzoyl]amino]pentanedioic acid |
50% growth inhibition of wild-type with plasmid expressing formate-tetrahydrofolate ligase |
700281 |