EC Number   |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
|---|
    1.14.14.19 | 0.00000035 |
- |
orteronel |
isoform P450 17A1, with pregnenolone as substrate, at pH 7.4b and 37°C |
734316 |
| 1.14.14.19 | 0.0000011 |
- |
orteronel |
isoform P450 17A2, with progesterone as substrate, at pH 7.4b and 37°C |
734316 |
| 1.14.14.19 | 0.000006 |
- |
6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-N-methyl-2-naphthamide |
in 75 mM phosphate buffer (pH 7.4), at 37°C |
714461 |
| 1.14.14.19 | 0.0000083 |
- |
1-(4'-fluoro[1,1'-biphenyl]-3-yl)-1-(1H-imidazol-4-yl)-2-methyl-1-propanol |
in 75 mM phosphate buffer (pH 7.4), at 37°C |
714465 |
| 1.14.14.19 | 0.00001 |
- |
(-)-7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-1,2-dihydro-3H-benzo[e]isoindol-3-one |
IC50 above 0.00001 mM, in 75 mM phosphate buffer (pH 7.4), at 37°C |
714461 |
| 1.14.14.19 | 0.00001 |
- |
(-)-7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one |
IC50 above 0.00001 mM, in 75 mM phosphate buffer (pH 7.4), at 37°C |
714461 |
| 1.14.14.19 | 0.00001 |
- |
1-(1H-imidazol-4-yl)-1-(4'-methoxy-[1,10-biphenyl]-3-yl)-2-methyl-1-propanol |
in 75 mM phosphate buffer (pH 7.4), at 37°C |
714465 |
| 1.14.14.19 | 0.00001 |
- |
4-(1H-imidazol-1-ylmethyl)phenyl biphenyl-4-sulfonate |
IC50 against 17,20-lyase activity, pH and temperature not specified in the publication |
714413 |
| 1.14.14.19 | 0.00001 |
- |
4-(1H-imidazol-1-ylmethyl)phenyl biphenyl-4-sulfonate |
inhibition of 17alpha-hydroxylase activity, pH not specified in the publication, temperature not specified in the publication |
714413 |
| 1.14.14.19 | 0.00001 |
- |
6-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-naphthamide |
IC50 above 0.00001 mM, in 75 mM phosphate buffer (pH 7.4), at 37°C |
714461 |
