EC Number   |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
|---|
    1.13.11.11 | -999 |
- |
more |
the enzymatic and cellular assays are influenced by many factors including detection product, reaction time and culture medium, which may cause the inconsistency of enzymatic and cellular inhibitory activities of test compounds. The IC50 values of all the test compounds derived from NFK assay are 2-3 times higher than that of Kyn adduct assay |
764267 |
| 1.13.11.11 | 0.000028 |
- |
4-(thiophen-3-yl)-1,2-oxazol-5-amine |
pH and temperature not specified in the publication |
763817 |
| 1.13.11.11 | 0.000029 |
- |
4-(thiophen-2-yl)-1,2-oxazol-5-amine |
pH and temperature not specified in the publication |
763817 |
| 1.13.11.11 | 0.00003 |
- |
(2E)-3-(8-fluoro-6,12-dioxo-6,12-dihydroindolo[2,1-b]quinazolin-2-yl)prop-2-enoic acid |
pH and temperature not specified in the publication |
764295 |
| 1.13.11.11 | 0.00003 |
- |
1-(3-[(4-methyl-1-piperazinyl)carbonyl]benzyl)-1H-naphtho-[2,3-d][1,2,3]triazole-4,9-dione |
pH 8.0, 37°C |
743064 |
| 1.13.11.11 | 0.00004 |
- |
(1R,2S)-2-[[(6-bromo-1H-indazol-4-yl)amino]methyl]cyclohexan-1-ol |
shows efficacy against the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse motor coordination deficits, comparable to Madopar, an anti-Parkinson's disease medicine, 22°C, pH 6.5 |
765226 |
| 1.13.11.11 | 0.000048 |
- |
1-[3-(4-morpholinylcarbonyl)benzyl]-1H-naphtho[2,3-d]-[1,2,3]triazole-4,9-dione |
pH 8.0, 37°C |
743064 |
| 1.13.11.11 | 0.000059 |
- |
1-(3-[(4-acetyl-1-piperazinyl)carbonyl]benzyl)-1H-naphtho-[2,3-d][1,2,3]triazole-4,9-dione |
pH 8.0, 37°C |
743064 |
| 1.13.11.11 | 0.00006 |
- |
8-fluoro-6,12-dioxo-6,12-dihydroindolo[2,1-b]quinazoline-2-carbaldehyde |
pH and temperature not specified in the publication |
764295 |
| 1.13.11.11 | 0.00009 |
- |
(1S,2R)-2-[[(6-bromo-1H-indazol-4-yl)amino]methyl]cyclohexan-1-ol |
22°C, pH 6.5 |
765226 |
