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Results 1 - 10 of 112 > >>
EC Number
IC50 Value
IC50 Value Maximum
Inhibitor
Commentary
Reference
-999
-
more
xanthine and related compounds inhibit CTPS activity with IC50 = 0.16-0.58 mM. The presence of an 8-oxo function enhances the inhibition to IC50 = 0.060-0.121 mM. Raising the pH from 8.0 to 8.5 results in slightly increased inhibition of NH3-dependent CTP formation by the xanthines
0.04
-
CTP
wild-type, pH 8.1, 37°C
0.042
-
CTP
wild-type, pH 8.1, 37°C
0.045
-
CTP
mutant S571A, pH 8.1, 37°C
0.05
-
CTP
IC50: 0.05 mM
0.057
-
CTP
C-terminal deletion mutant, pH 8.1, 37°C
0.06
-
uric acid
pH 8.0, Gln-dependent CTP formation
0.063
-
3,7-dimethyluric acid
pH 8.0, Gln-dependent CTP formation
0.067
-
1,3,7-trimethyluric acid
pH 8.0, Gln-dependent CTP formation
0.07
-
1,3,7-trimethyluric acid
pH 8.0, NH3-dependent CTP formation
Results 1 - 10 of 112 > >>