EC Number |
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5.6.1.6 | 3D structure constructed by molecular modeling. Residue F508 mediates a tertiary interaction between the surface of nucleotide-binding domain 1 and a cytoplasmic loop in the C-terminal membrane-spanning domain |
5.6.1.6 | by hanging drop method, at 20 A resolution in the xy plane, at 30 A resolution along z plane, two crystal forms, one with a roughly hexagonal profile, the other with an opened-out triangular profile, the two conformations are in presence of a nucleotide, which may be related to the role of CFTR as an ion channel rather than a transporter, and may represent the open and closed states of the channel |
5.6.1.6 | cryo-electron microscopy |
5.6.1.6 | inactive and active states of a thermally stabilized enzyme, cryo-electron microscopy |
5.6.1.6 | mutant enzyme F508del, microbatch method, using 40% (w/v) PEG 400, 100 mM NH4Cl, and 100 mM MES, pH 6.0 |
5.6.1.6 | native and selenomethionyl nucleotide-binding domain 1, hanging-drop vapor-diffusion method |