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EC Number Crystallization (Commentary) Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.11.15the 12-subunit PhTET3 complex is crystallized and its 3D structure is solved at a resolution of 1.9 A by molecular replacement 723211
Display the word mapDisplay the reaction diagram Show all sequences 3.4.11.15x-ray crystal structure of the Co(II)-loaded form ([CoCo(AAP)]) is solved to 2.2 A resolution. [CoCo(AAP)] folds into an alpha/beta globular domain with a twisted beta-sheet hydrophobic core sandwiched between alpha-helices, identical to [ZnZn(AAP)]. Tris(hydroxymethyl)aminomethane coordinates to the dinuclear Co(II) active site of AAP with one of the Tris hydroxyl oxygen atoms (O4) forming a single oxygen atom bridge between the two Co(II) ions. This is the only Tris atom coordinated to the metals with Co1-O and Co2-O bonds distances of 2.2 and 1.9 A, respectively. Each of the Co(II) ions resides in a distorted trigonal bipyramidal geometry 683745
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