   3.1.3.36 | in complex with biphenyl 3,3',4,4',5,5'-hexakisphosphate, to 2.89 A resolution. One inhibitor pole locates in the phospholipid headgroup binding site and the second solvent-exposed ring binds to the His-Tag of another INPP5B molecule, while a molecule of inorganic phosphate is also present in the active site. In complex with benzene 1,2,4,5-tetrakisphosphate, to 2.9 A resolution. Conserved residues among the 5-phosphatase family mediate interactions with the inhibitors similar to those with the polar groups present in positions 1, 4, 5, and 6 on the inositol ring of the substrate. 5-Phosphatase specificity most likely resides in the variable zone located close to the 2- and 3-positions of the inositol ring |
