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EC Number Crystallization (Commentary) Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.1.1.89crystal structures of methylesterase PME-1 by itself and in complex with a protein phosphatase PP2A heterodimeric core enzyme, to 2.0 and 2.7 A resolution. PME-1 directly binds to the active site of protein phosphatase PP2A and this interaction results in the activation of PME-1 by rearranging the catalytic triad into an active conformation. These interactions also lead to inactivation of protein phosphatase PP2A by evicting the manganese ions that are required for the phosphatase activity of PP2A. PME-1 fdisplays a dual role that regulates protein phosphatase PP2A activation, methylation, and holoenzyme assembly in cells 722006
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