EC Number |
Ki Value [mM] |
Ki Value maximum [mM] |
Inhibitor |
Reference |
---|
1.1.1.270 | 0.0001 |
- |
trilostane |
3beta-HSD1 wild-type, pH 7.4, 27°C |
725813 |
1.1.1.270 | 0.0001 |
- |
trilostane |
pH 7.4, 27°C, wild-type enzyme |
763397 |
1.1.1.270 | 0.00019 |
- |
trilostane |
3beta-HSD2 mutant P195R, pH 7.4, 27°C |
725813 |
1.1.1.270 | 0.00067 |
- |
trilostane |
pH 7.4, 27°C, chimeric S194G-1 mutant |
763397 |
1.1.1.270 | 0.0016 |
- |
trilostane |
3beta-HSD2 wild-type, pH 7.4, 27°C |
725813 |
1.1.1.270 | 0.00256 |
- |
trilostane |
3beta-HSD1 mutant R195P, pH 7.4, 27°C |
725813 |
1.1.1.270 | 0.00256 |
- |
trilostane |
pH 7.4, 27°C, chimeric 195P-1 mutant |
763397 |
1.1.1.270 | 0.0047 |
- |
2,16-dicyano-4,5-epoxy-androstane-3,17-dione |
pH 7.4, 27°C, wild-type enzyme |
763397 |
1.1.1.270 | 0.0295 |
- |
2,16-dicyano-4,5-epoxy-androstane-3,17-dione |
pH 7.4, 27°C, chimeric S194G-1 mutant |
763397 |
1.1.1.270 | 0.0415 |
- |
2,16-dicyano-4,5-epoxy-androstane-3,17-dione |
pH 7.4, 27°C, chimeric 195P-1 mutant |
763397 |