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Results 1 - 10 of 22 > >>
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EC Number Cofactor Commentary Reference
Show all pathways known for 4.1.1.28Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.28more no absolute requirement for exogenous pyridoxal 5'-phosphate 650450
Show all pathways known for 4.1.1.28Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.28pyridoxal 5'-phosphate - 649601, 649696, 650410, 650436, 650868, 653346, 653352, 653356, 653443, 665420, 666154, 690973, 691469, 691846, 691888, 691987, 692200, 692593, 693382, 694362, 701921, 702954, 702968, 703136, 703575, 704020, 704084, 704491, 704803, 705269, 705914, 715979, 716172, 716467, 716702, 743976, 743977, 744008, 744251, 744252, 745291, 748845
Show all pathways known for 4.1.1.28Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.28pyridoxal 5'-phosphate (vitamin B6), patients with AAAD deficiency receives a therapeutic trial with pyridoxal-5'-phosphate, individual dosage varies between 150 and 4800 mg/day (20-160 mg/kg per day). 4 of 9 patients improved slightly on vitamin B6 (3 of them are siblings with a special L-dopa responsive mutation). There is no change in CSF neurotransmitter findings in all investigated patients. Side effects are predominantly gastrointestinal, such as nausea, vomiting and abdominal pain. 693490
Show all pathways known for 4.1.1.28Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.28pyridoxal 5'-phosphate 0.001-0.1 mM, stimulates 2fold to 3fold 4232
Show all pathways known for 4.1.1.28Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.28pyridoxal 5'-phosphate 0.0032-0.32 mM, enhances activity greater than 2fold 4212
Show all pathways known for 4.1.1.28Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.28pyridoxal 5'-phosphate 1 mol of pyridoxal 5'-phosphate is bound to the epsilon-amino group of a lysyl residue of the apoenzyme 4218
Show all pathways known for 4.1.1.28Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.28pyridoxal 5'-phosphate 5-hydroxytryptophan can be decarboxylated without exogenous addition of pyridoxal 5'-phosphate, addition of pyridoxal 5'-phosphate substantially increases enzyme activity. Excess of coenzyme, above 0.06 mM, induces inhibition in adrenals and liver but not in the central nervous system 4215
Show all pathways known for 4.1.1.28Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.28pyridoxal 5'-phosphate addition of pyridoxal 5'-phosphate increases activity towards 3,4-dihydroxyphenylalanine, o-Tyr, m-Tyr, but not towards 5-hydroxytryptophan 4213
Show all pathways known for 4.1.1.28Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.28pyridoxal 5'-phosphate binding site is located at the amino acid position 313-334 726645
Show all pathways known for 4.1.1.28Display the word mapDisplay the reaction diagram Show all sequences 4.1.1.28pyridoxal 5'-phosphate cofactor 4202
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