EC Number   |
Cofactor |
Reference |
|---|
   3.4.21.69 | chondroitin sulfate |
anticoagulant cofactor for APC |
653966 |
| 3.4.21.69 | dermatan sulfate |
anticoagulant cofactor for APC, important physiological cofactor |
653966 |
| 3.4.21.69 | heparan sulfate |
anticoagulant cofactor for APC |
653966 |
| 3.4.21.69 | more |
presence of the APC cofactor, protein S, thrombomodulin, endothelial protein C receptor and a phospholipid surface are important for the expression of anticoagulant APC activity, mechanism, overview |
718418 |
| 3.4.21.69 | more |
protein S not only down-regulates factor VIIIa activity as a cofactor of activated protein C, but also directly impairs the assembly of the factor Xase complex, independent of activated protein C, in a competitive interaction between factor IXa and factor VIIIa |
697024 |
| 3.4.21.69 | protein S |
- |
752736, 753065 |
| 3.4.21.69 | protein S |
complexed witht the activated protein C, increases the activity 6-10fold |
683295 |
| 3.4.21.69 | protein S |
from human plasma, interacts with the autolysis loop of the enzyme |
683258 |
| 3.4.21.69 | protein S |
inhibits the inhibition of factor Va cleavage by factor Xa, factor Xa and protein S interact with distinct sites on FVa |
683629 |
| 3.4.21.69 | protein S |
required, activates, the position of APC Gla domain residues is critical for protein S enhancement of APC activity and EPCR recognition, binding structure, overview |
683627 |
