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EC Number Cofactor Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.68more native and recombinant beta2-glycoprotein I or its domain V stimulate tPA-dependent plasminogen activation in a concentration-dependent manner. Beta2-glycoprotein I binds tPA with high affinity (Kd =20 nmol), stimulates tPA amidolytic activity, and causes an overall 20fold increase in the catalytic efficiency (kcat/Km) of tPA-mediated conversion of Glu-plasminogen to plasmin 695959
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