EC Number   |
Cofactor |
Reference |
|---|
   2.7.1.137 | ATP |
- |
660643, 660688, 661498, 661766, 661892, 663296, 688155, 707040, 707454, 707877, 707930, 708145, 708146, 708336, 708417, 708568, 708595, 708644, 708681, 708779, 708996, 709003, 709207, 709341, 709342, 709478, 709630, 710020, 710074, 710515, 738465, 739359, 760521, 760661, 761792, 761826, 762179 |
| 2.7.1.137 | ATP |
as MgATP2- |
661681 |
| 2.7.1.137 | ATP |
binding site structure, a single conserved residue 884, termed the gatekeeper, controls the sensitivity to a wide range of small molecule inhibitors, inhibitor resistance is conferred by a large resiude at this position, e.g. isoleucine, whereas a small amino acid at this position like alanine, glycine, or threonine renders the enzyme sensitive for inhibition by small molecule drugs, the effect can be reversed by mutation of residue C838 to valine or isoleucine |
661328 |
| 2.7.1.137 | ATP |
binding site structure, a single conserved residue I670 of VPS34 and L2129 of PI3-K-related protein MEC1, termed the gatekeeper, controls the sensitivity to a wide range of small molecule inhibitors, inhibitor resistance id conferred by a large resiude at this position, e.g. isoleucine, whereas a small amino acid at this position like alanine, glycine, or threonine renders the enzyme sensitive for inhibition by small molecule drugs |
661328 |
