EC Number |
Cofactor |
Reference |
---|
1.2.1.48 | NAD+ |
- |
347796, 390320, 390323, 656817, 693389, 724462, 725656, 741853, 762634, 762884, 763641 |
1.2.1.48 | NAD+ |
a series of ALDHs have been shown to bind NAD in a conformation that results in a pro-R-specific hydride transfer during catalysis. The hydride transfer in FALDH is clearly pro-R specific. Residue Glu331 interacts with the ribose-backbone of NAD and assists correct cofactor binding and orientation |
743336 |
1.2.1.48 | NAD+ |
activity of Bt-Aldh is doubled in the presence of NAD+ than NADP+ |
697840 |
1.2.1.48 | NAD+ |
NAD+ is a much better electron acceptor than NADP+, FAD or flavin mononucleotide |
389732, 94404 |
1.2.1.48 | NAD+ |
the enzyme does not use NADP+ as cofactor |
390325 |
1.2.1.48 | NAD+ |
the enzyme has a much greater specificity for NAD+ as cofactor than NADP+ |
390324 |
1.2.1.48 | NADH |
- |
697840 |
1.2.1.48 | NADP+ |
- |
697840 |
1.2.1.48 | NADP+ |
very high specificity and affinity, the residue Arg-210 contributes to the high cofactor affinity through a pi stacking interaction with the adenine ring system of the cofactor |
390326 |
1.2.1.48 | NADPH |
about 50% of the activity with NADH |
697840 |