EC Number |
Cofactor |
Reference |
---|
1.2.1.105 | 3-acetylpyridine adenine dinucleotide |
3-acetylpyridine adenine dinucleotide can be used instead of NAD+ to avoid concomitant oxidase activity that would degrade NADH produced by the ODH reaction |
687856 |
1.2.1.105 | CoA |
- |
758747 |
1.2.1.105 | lipoic acid |
increases KGDHC activity in aged rates |
676088 |
1.2.1.105 | lipoic acid |
leads to a stabilization of cognitive functions in Alzheimer's disease patients |
676088 |
1.2.1.105 | more |
2-oxoglutarate dehydrogenase complex contains FAD |
349026 |
1.2.1.105 | more |
2-oxoglutarate dehydrogenase complex contains protein-bound lipoic acid |
349026 |
1.2.1.105 | more |
EC 1.8.1.4, dihydrolipoyl dehydrogenase component of the 2-oxoglutarate dehydrogenase complex is a flavin protein |
349038 |
1.2.1.105 | more |
EC 2.3.1.61, dihydrolipoamide succinyltransferase component of the 2-oxoglutarate dehydrogenase enzyme complex contains a lipoate moiety that is covalently bound to Lys110 through an epsilon-amide linkage. The thiamine diphosphate reaction adduct then reductively acylates the lipoyl moiety of EC 2.3.1.61 |
349038 |
1.2.1.105 | more |
lipoyl moiety, LipS2, is bound in amide linkage to the epsilon amino group of a lysine residue |
349004 |
1.2.1.105 | more |
the complex contains 12 lipoyl groups |
349019 |