EC Number   |
Cofactor |
Reference |
|---|
   1.2.1.104 | CoA |
- |
759422, 759746 |
| 1.2.1.104 | more |
CoA and NAD+ required by pyruvate dehydrogenase complex |
348924 |
| 1.2.1.104 | NAD+ |
- |
655234, 656580, 656612, 687812, 695486, 695494, 696036, 699383, 700076, 700800, 710828, 711033, 711542, 712006, 712786, 713056, 713120, 759422, 759746 |
| 1.2.1.104 | NADH |
- |
735848, 759746 |
| 1.2.1.104 | thiamine diphosphate |
- |
348948, 348950, 348954, 348969, 348970, 348971, 348973, 348976, 348977, 348978, 348980, 655234, 687353, 687748, 687812, 690088, 710828, 711033, 712006, 712786, 713120, 758852 |
| 1.2.1.104 | thiamine diphosphate |
Km value 0.0034 mM for overall reaction |
672469 |
| 1.2.1.104 | thiamine diphosphate |
only one of the two thiamine molecules bound to the two active sites of the alpha2beta2 E1 component is in a chemically activated state exhibiting an apparent C2 ionization rate constant of approximately 50 per s at pH 7.6 and 30°C, whereas the thiamine in the inactive site ionizes with a rate that is at least 3 orders of magnitude smaller |
758780 |
| 1.2.1.104 | thiamine diphosphate |
two binding sites |
348912 |
