EC Number |
Cofactor |
Reference |
---|
1.14.16.1 | (6R)-5,6,7,8-tetrahydro-L-monapterin |
7% of the activity with tetrahydrobiopterin |
687580 |
1.14.16.1 | (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin |
- |
699374, 712471 |
1.14.16.1 | (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin |
i.e. 6(R)BH4, essential cofactor |
673511 |
1.14.16.1 | (7R)-tetrahydrobiopterin |
8fold lower affinity and activity compared with 6(R)BH4 |
673511 |
1.14.16.1 | (7S)-tetrahydrobiopterin |
8fold lower affinity and activity compared with 6(R)BH4 |
673511 |
1.14.16.1 | 5,6,7,8-tetrahydro-L-biopterin |
- |
659643, 696226, 697593, 697799, 697830, 699022, 699060, 699235, 699316, 699746, 700231, 701083 |
1.14.16.1 | 5,6,7,8-tetrahydro-L-biopterin |
PAH can be activated up to 20times in the presence of its natural cofactor 5,6,7,8-tetrahydro-L-biopterin but cannot be activated in the presence of synthetic cofactors such as 6,7-dimethyltetrahydrobiopterin or 6-methyltetrahydropterin |
700235 |
1.14.16.1 | 5,6,7,8-tetrahydrobiopterin |
- |
672057 |
1.14.16.1 | 6,7-dimethyl-5,6,7,8-tetrahydrobiopterin |
- |
659519 |
1.14.16.1 | 6,7-dimethyltetrahydropterin |
17% of the activity with tetrahydrobiopterin |
687580 |