EC Number |
Cofactor |
Reference |
---|
1.1.1.85 | NAD+ |
- |
639130, 639131, 639132, 639133, 639135, 639136, 639137, 639138, 639139, 639140, 639141, 639142, 639143, 639144, 639145, 639146, 639147, 639148, 639149, 639150, 639151, 639152, 639153, 639154, 639155, 639156, 639157, 639158, 639159, 639160, 639161, 639162, 639163, 639164, 639167, 639168, 656556, 657223, 668015, 668635, 669872, 696778, 701046, 737729, 737867, 738191, 738212, 738239, 738685, 739436, 739458, 762701 |
1.1.1.85 | NAD+ |
cofactor binding structure, 100fold preference to NADP+ |
670886 |
1.1.1.85 | NAD+ |
dependent on |
738195 |
1.1.1.85 | NAD+ |
dependent on, cofactor specificity-determining residues, overview |
670847 |
1.1.1.85 | NAD+ |
Km value 0.15 mM, NAD+ is favoured over NADP+ |
680429 |
1.1.1.85 | NAD+ |
NAD+ binding induces a conformational transition in IMDH |
639165 |
1.1.1.85 | NAD+ |
specific for NAD+, activity drops to less than 5% when NADP+ is substituted for NAD+ |
639134 |
1.1.1.85 | NAD+ |
the acidic tip of IPM-Glu88 is likely to interact with the nicotinamide mononucleotide ribose of NAD+ in the ternary complex. This structure clearly explains the substrate specificity of IPMDH |
639166 |
1.1.1.85 | NADH |
- |
639162, 656556, 710765, 711150, 711444 |
1.1.1.85 | NADP+ |
- |
639155 |