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EC Number Cloned (Commentary) Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.19.6detection of a RNA species derived from an alternative processing at the exon 14–intron 14 boundary. The alternatively processed RNA encodes a shorter version of PPII (PPII*), lacking part of the C-terminal domain. PPII* is expressed in COS-7 (or C6 glioma) cells but it does not exhibit any PPII activity. Co-transfection of PPII and increasing amounts of PPII* expression vectors results in a dose-dependent reduction in PPII activity and the formation of covalent PPII–PPII* heterodimers. PPII* is therefore a powerful dominant-negative isoform of PPII, and heterodimerization may be its mechanism of action. Natural expression of shortened versions of M1 aminopeptidases may constitute a new mode of regulation of their activity 669931
Display the word mapDisplay the reaction diagram Show all sequences 3.4.19.6full-length enzyme, mutant enzymes and truncated enzyme 647287
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