EC Number   |
Subunits |
Reference |
|---|
   3.4.22.63 | ? |
x * 40000, caspase-10/c, SDS-PAGE |
647713 |
| 3.4.22.63 | ? |
x * 58900 Da, calculated, not proteolytically activated |
696452 |
| 3.4.22.63 | ? |
x * 61700, calculated from sequence |
753725 |
| 3.4.22.63 | dimer |
caspase-10 follows the proximity-induced dimerization model for apical caspases. Chemically inducible dimerization fusions activate the wild-type but not the cleavage site mutant caspase-10 |
717252 |
| 3.4.22.63 | dimer |
caspases can only be active as dimers, since neither the active site dyad nor the substrate pocket can be formed in the monomeric form |
717282 |
| 3.4.22.63 | monomer |
1 * 61000, about, sequence calculation, mature enzyme, 1 * 103500, recombinant maltose-binding protein-fusion enzyme, SDS-PAGE |
731832 |
| 3.4.22.63 | More |
homology modelling of caspase-10, structural modeling based on the structure of procaspase-8, PDB ID 2K7Z |
717252 |
| 3.4.22.63 | More |
proMch4 can autoprocess after Asp-219 and Asp-372 to generate the two subunits of the mature enzyme: P17, the large subunit and p12, the small subunit |
647447 |
| 3.4.22.63 | More |
the enzyme contains two death effector domains (DED) in the N-terminal at 2-77 and 87-154 and it contains caspase family p20 domain (large subunit) and caspase family p10 domain (small subunit) in the C-terminal at 299-425 and 449-536 respectively |
731832 |
